{"id":10,"date":"2022-09-06T11:07:01","date_gmt":"2022-09-06T11:07:01","guid":{"rendered":"https:\/\/ncodelab.org\/?page_id=10"},"modified":"2025-09-04T10:15:39","modified_gmt":"2025-09-04T10:15:39","slug":"research","status":"publish","type":"page","link":"https:\/\/ncodelab.org\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:calc( 1200px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:0px;--awb-margin-bottom-large:0px;--awb-spacing-left-large:0px;--awb-width-medium:100%;--awb-spacing-right-medium:0px;--awb-spacing-left-medium:0px;--awb-width-small:100%;--awb-spacing-right-small:0px;--awb-spacing-left-small:0px;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><\/p>\n<p>We develop quantitative methods on neurophysiological large datasets to investigate brain information processing during cognition and disease. In particular, we are interested in the mechanisms by which stimuli, behavioral responses, and pathological states are encoded and distributed through the simultaneous activity of multiple brain areas. In our studies, we mainly analyze single-cell (spike train) and neural population (human intracranial EEG) data.<\/p>\n<\/p>\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/p>\n<h3 data-fontsize=\"32\" style=\"--fontSize:32; line-height: 1.3;\" data-lineheight=\"41.6px\" class=\"fusion-responsive-typography-calculated wp-block-heading\">Temporal and spatial characterization of epileptic networks<\/h3>\n<\/p>\n<p>We study the emergence and maintenance of the pre-ictal state (the brain state prior to epileptic seizures) by means of dynamic functional connectivity analysis of long-lasting periods (~12 hours) of intracranial data from epileptic patients [1,2]. <span style=\"background-color: var(--awb-bg-color-hover); color: var(--awb-text-color); font-family: var(--awb-text-font-family); font-size: var(--awb-font-size); font-style: var(--awb-text-font-style); font-weight: var(--awb-text-font-weight); letter-spacing: var(--awb-letter-spacing); text-align: var(--awb-content-alignment); text-transform: var(--awb-text-transform);\">We are also interested in spatially determining the main brain areas where seizures begin (&#8220;focus&#8221;). With this regard, we have recently developed quantitative tools to predict seizure focus localization for pre-surgical diagnosis [3,4].<\/span><\/p>\n<p><br><\/p>\n<div class=\"wp-block-group\">\n<\/div>\n<p><!-- \/wp:post-content --><\/p>\n<\/div><div class=\"fusion-text fusion-text-2\"><p><!-- wp:paragraph --><\/p>\n<p><strong style=\"font-size: 14px; color: var(--awb-text-color); font-family: var(--awb-text-font-family); font-style: var(--awb-text-font-style); letter-spacing: var(--awb-letter-spacing); text-align: var(--awb-content-alignment); text-transform: var(--awb-text-transform); background-color: var(--awb-bg-color-hover);\">Selected publications<\/strong><br><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:group --><\/p>\n<div class=\"wp-block-group\"><!-- wp:group {\"layout\":{\"type\":\"flex\",\"orientation\":\"vertical\"}} --><\/p>\n<div class=\"wp-block-group\"><!-- wp:list {\"fontSize\":\"small\"} --><\/p>\n<ul class=\"has-small-font-size\">\n<li>[1] &#8220;<a href=\"http:\/\/journals.plos.org\/plosbiology\/article?id=10.1371\/journal.pbio.2002580\">Degenerate time-dependent network dynamics anticipate seizures in human epileptic brain<\/a>&#8220;, A. Tauste Campo, A. Principe, M. Ley, R. Rocamora and G. Deco. PLoS Biology, 6(4): e2002580, 2018.<\/li>\n<li>[2] &#8220;<a href=\"https:\/\/iopscience.iop.org\/article\/10.1088\/1741-2552\/adf097\" target=\"_blank\" rel=\"noopener noreferrer\">Preictal high-connectivity states in epilepsy: Evidence of intracranial EEG, interplay with the seizure onset zone and network modeling<\/a>&#8220;, N. Medina, M. Vila-Vidal, A. Tost, M. Khawaja, M. Carre\u00f1o, P. Rold\u00e1n, J. Rumi\u00e0, M. Centeno, E. Conde, A. Donaire, A. Tauste Campo. Journal of Neural Engineering, 2025.<\/li>\n<li>[3] &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1388245717301372\">Detection of recurrent activation patterns across focal seizures: Application to seizure onset zone identification<\/a>&#8220;. M. Vila-Vidal, A. Principe, M. Ley, G. Deco, A. Tauste Campo* and R. Rocamora*. Clinical Neurophysiology, 128:977-85, 2017.<\/li>\n<li>[4] &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1053811919310018?via%3Dihub\">Low entropy map of brain oscillatory activity identifies spatially localized events: A new method for automated epilepsy focus prediction<\/a>&#8220;. M. Vila-Vidal, C. P\u00e9rez-Enr\u00edquez, A. Principe, R. Rocamora, G. Deco, A. Tauste Campo. Neuroimage, vol. 208, 116410, 2020.<\/li>\n<\/ul>\n<p><!-- \/wp:list --><\/p>\n<\/div>\n<p><!-- \/wp:group --><\/p>\n<p><!-- wp:spacer {\"height\":\"20px\"} --><\/p>\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<p><!-- \/wp:spacer --><\/p>\n<p><!-- wp:heading {\"level\":3} --><\/p>\n<h3 data-fontsize=\"32\" style=\"--fontSize:32; line-height: 1.3;\" data-lineheight=\"41.6px\" class=\"fusion-responsive-typography-calculated\">Neural coding and neural communication <\/h3>\n<p><span style=\"color: var(--awb-text-color); font-family: var(--awb-text-font-family); font-size: var(--awb-font-size); font-style: var(--awb-text-font-style); font-weight: var(--awb-text-font-weight); letter-spacing: var(--awb-letter-spacing); text-align: var(--awb-content-alignment); text-transform: var(--awb-text-transform); background-color: var(--awb-bg-color-hover);\">We are interested in the neural coding problem and in particularly, in relating this problem to that of information transmission. We have mainly studied both problems in the context of reward-driven perceptual tasks in monkeys  to characterize the thalamo-cortical [1,2] and cortical-cortical directed functional paths [3] that are activated during these tasks.<\/span><\/p>\n<\/div>\n<div class=\"wp-block-group\">\n<p><!-- \/wp:heading --><\/p>\n<\/div>\n<p><!-- \/wp:group --><\/p>\n<\/div><div class=\"fusion-image-element \" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"1024\" height=\"296\" title=\"Information_flow_bis\" src=\"https:\/\/ncodelab.org\/wp-content\/uploads\/2025\/07\/Information_flow_bis-pdf-1024x296.jpg\" alt class=\"img-responsive wp-image-408\"\/><\/span><\/div><div class=\"fusion-text fusion-text-3\"><p><!-- wp:paragraph --><\/p>\n<p><strong style=\"font-size: 14px; color: var(--awb-text-color); font-family: var(--awb-text-font-family); font-style: var(--awb-text-font-style); letter-spacing: var(--awb-letter-spacing); text-align: var(--awb-content-alignment); text-transform: var(--awb-text-transform); background-color: var(--awb-bg-color-hover);\">\u00a1Selected publications<\/strong><br><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:list {\"fontSize\":\"small\"} --><\/p>\n<ul class=\"has-small-font-size\">\n<li>[1] A. Tauste Campo, A. Zainos, Y. V\u00e1zquez, R. Adell Segarra, M. \u00c1lvarez, G. Deco, H. D\u00edaz, S. Parra, R. Romo, R. Rossi-Pool. \u201c<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2589004224012902\" target=\"_blank\" rel=\"noopener noreferrer\">Thalamocortical interactions shape hierarchical neural variability during stimulus perception<\/a>\u201c, iScience, vol. 27, no. 7, 110065, July 2024.<\/li>\n<li>[2] &#8220;<a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.1819095116\" target=\"_blank\" rel=\"noopener noreferrer\">Feedforward information and zero-lag synchronization in the sensory thalamo-cortical circuit are modulated during stimulus perception<\/a>&#8220;. A. Tauste Campo, Y. V\u00e1zquez, M. \u00c0lvarez, A. Zainos, R. Rossi-Pool, G. Deco, R Romo. PNAS, 116(15): 7513-22, 2019.<\/li>\n<li>[3] &#8220;<a href=\"http:\/\/www.pnas.org\/content\/112\/15\/4761.abstract\">Task-driven intra- and interarea communications in primate cerebral cortex<\/a>&#8220;. A. Tauste Campo, M. Martinez-Garcia, V. N\u00e1cher, R. Luna, R. Romo and G. Deco. PNAS, 112(15): 4761-6, 2015.<\/li>\n<\/ul>\n<p><!-- \/wp:list --><\/p>\n<p><!-- wp:spacer {\"height\":\"20px\"} --><\/p>\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<p><!-- \/wp:spacer --><\/p>\n<p><!-- wp:heading {\"level\":3} --><\/p>\n<h3 data-fontsize=\"32\" style=\"--fontSize:32; line-height: 1.3;\" data-lineheight=\"41.6px\" class=\"fusion-responsive-typography-calculated\"><strong>Computational models and methods<\/strong><\/h3>\n<p><!-- \/wp:heading --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>We have contributed to develop non-parametric statistical methods for non-linear [1] and linear models [2] for the inference of functional connectivity pathways using multiple and simultaneous brain area recordings.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph {\"style\":{\"typography\":{\"fontSize\":\"14px\"}}} --><\/p>\n<p style=\"font-size:14px\"><strong>Selected publications<\/strong><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:list {\"fontSize\":\"small\"} --><\/p>\n<ul class=\"has-small-font-size\">\n<li>[1]  &#8220;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2001037020303913?via%3Dihub\">Inferring neural information flow from spiking data<\/a>&#8220;, A. Tauste Campo, Computational and Structural Biotechnology Journal, vol. 18, pp. 2699-708, 2020.<\/li>\n<li>[2] &#8220;<a href=\"https:\/\/www.biorxiv.org\/content\/early\/2017\/03\/17\/100669\">Non-parametric test for connectivity detection in multivariate autoregressive networks and application to multiunit activity data<\/a>&#8220;, M. Gilson*, A. Tauste Campo*, X. Chen, A. Thiele, G. Deco, Network Neuroscience, 1(4): 357-80, 2017.<\/li>\n<\/ul>\n<p><!-- \/wp:list --><\/p>\n<p><!-- wp:group --><\/p>\n<div class=\"wp-block-group\"><!-- wp:columns --><\/p>\n<div class=\"wp-block-columns\"><!-- wp:column {\"verticalAlignment\":\"top\",\"width\":\"100%\"} --><\/p>\n<div class=\"wp-block-column is-vertically-aligned-top\" style=\"flex-basis:100%\"><!-- wp:group {\"layout\":{\"type\":\"flex\",\"orientation\":\"vertical\"}} --><\/p>\n<div class=\"wp-block-group\"><!-- wp:group --><\/p>\n<div class=\"wp-block-group\"><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div>\n<p><!-- \/wp:group --><\/p>\n<\/div>\n<p><!-- \/wp:group --><\/p>\n<\/div>\n<p><!-- \/wp:column --><\/p>\n<\/div>\n<p><!-- \/wp:columns --><\/p>\n<\/div>\n<p><!-- \/wp:group --><\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ncodelab.org\/index.php\/wp-json\/wp\/v2\/pages\/10","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ncodelab.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ncodelab.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ncodelab.org\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ncodelab.org\/index.php\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":29,"href":"https:\/\/ncodelab.org\/index.php\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"predecessor-version":[{"id":409,"href":"https:\/\/ncodelab.org\/index.php\/wp-json\/wp\/v2\/pages\/10\/revisions\/409"}],"wp:attachment":[{"href":"https:\/\/ncodelab.org\/index.php\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}